Author

N. R. Brun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:zebrafish· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. J. Stegeman· 2 shared J. V. Goldstone· 2 shared M. C. Salanga· 2 shared D. C. Lamb· 1 shared E. Ivashkin· 1 shared F. X. Mora-Zamorano· 1 shared J. Goldstone· 1 shared J. M. Panlilio· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. J. Stegeman

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Orphan cytochrome P450 20A1 CRISPR/Cas 9 mutants and neurobehavioral phenotypes in zebrafish

N. R. Brun, M. C. Salanga, F. X. Mora-Zamorano, D. C. Lamb, J. V. Goldstone, J. J. Stegeman

This study creates zebrafish CYP20A1 mutants using CRISPR/Cas9 and finds behavioral differences suggesting a neurophysiological role for CYP20A1.

bioRxiv · Jul 23, 2021Pharmacology & Toxicology

Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs)

N. R. Brun, J. M. Panlilio, K. Zhang, Y. Zhao, E. Ivashkin, J. Stegeman, J. Goldstone

This study investigates the neurobehavioral effects of PCB153 exposure in zebrafish, finding delayed startle responses and disrupted dopaminergic and GABAergic signaling.

bioRxiv · Feb 14, 2021Pharmacology & Toxicology

CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cytochrome p450 family 3, subfamily A, polypeptide 65 (cyp3a65) in zebrafish (Danio rerio) larvae.

M. C. Salanga, N. R. Brun, R. Francolini, J. J. Stegeman, J. V. Goldstone

This study shows zebrafish pxr mutants retain cyp3a65 induction after pregnenolone exposure, suggesting compensatory mechanisms or functional truncated Pxr.

bioRxiv · May 30, 2019Pharmacology & Toxicology