Durable Control of HIV-1 Using a Staphylococcus aureus Cas9-Expressing Lentivirus Co-Targeting Viral Latency and Host Susceptibility
L. R. Chavez, N. R. Reddy, K. A. Raymond, M. S. Bouzidi, S. Desai, Z. Y. Dossani, H. S. Sperber, J. Theiler, B. Korber, S. K. Pillai
This study develops a lentiviral vector targeting both HIV-1 provirus and host CXCR4 to reduce gene editing efficacy thresholds for an HIV-1 cure.
bioRxiv · Aug 10, 2020 · PreprintMicrobiology