Author

H. S. Sperber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. A. Raymond· 3 shared M. S. Bouzidi· 3 shared S. K. Pillai· 3 shared R. Schwarzer· 2 shared A. D. Werts· 1 shared A. G. Gutierrez· 1 shared A. Herrmann· 1 shared A. M. Healy· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

K. A. Raymond

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency

H. S. Sperber, K. A. Raymond, M. S. Bouzidi, T. Ma, S. Valdebenito, E. Eugenin, N. R. Roan, S. G. Deeks, S. Winning, J. Fandrey, R. Schwarzer, S. K. Pillai

This study identifies CD73 as a marker of HIV latency, showing hypoxia enhances its expression and adenosine signaling promotes viral quiescence.

bioRxiv · Aug 3, 2022Microbiology

Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE-2 in vitro

K. Khanna, W. Raymond, J. Jin, A. R. Charbit, I. Gitlin, M. Tang, A. D. Werts, E. G. Barrett, J. M. Cox, S. M. Birch, R. Martinelli, H. S. Sperber, S. Franz, S. Pillai, A. M. Healy, , J. V. Fahy

Thiol drugs inhibit SARS-CoV-2 infection in vitro and reduce lung injury in vivo, supporting their potential as COVID-19 treatments.

bioRxiv · Dec 8, 2020 · PreprintMicrobiology

μ-Lat: A Mouse Model to Evaluate Human Immunodeficiency Virus Eradication Strategies

H. S. Sperber, P. P. Togarrati, K. A. Raymond, M. S. Bouzidi, R. Gilfanova, A. G. Gutierrez, M. O. Muench, S. K. Pillai

The paper develops a humanized mouse model to evaluate HIV eradication strategies by transplanting J-Lat cells and testing TNF's effect on viral reactivation.

The FASEB Journal · Sep 9, 2020Peer-reviewedMicrobiology

Durable Control of HIV-1 Using a Staphylococcus aureus Cas9-Expressing Lentivirus Co-Targeting Viral Latency and Host Susceptibility

L. R. Chavez, N. R. Reddy, K. A. Raymond, M. S. Bouzidi, S. Desai, Z. Y. Dossani, H. S. Sperber, J. Theiler, B. Korber, S. K. Pillai

This study develops a lentiviral vector targeting both HIV-1 provirus and host CXCR4 to reduce gene editing efficacy thresholds for an HIV-1 cure.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

R. R. Nair, D. Zabezhinsky, R. Gelin-Licht, B. J. Haas, M. C. A. Dyhr, H. S. Sperber, C. Nusbaum, J. E. Gerst

The paper identifies transperons in yeast, multiplexed mRNP particles formed by mRNAs from different chromosomes, and shows their dependence on H4 histones for function.

bioRxiv · Jun 28, 2020Cell Biology

Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.

S. Bauherr, F. Larsberg, A. Petrich, H. S. Sperber, V. Klose, W. Azab, M. Schade, M. Luckner, C. T. Höfer, M. J. Lehmann, P. T. Witkowski, D. H. Krüger, A. Herrmann, R. Schwarzer

This study shows that Puumala virus uses both macropinocytosis and clathrin-mediated endocytosis for entry into mammalian cells, and inhibiting these pathways reduces infection.

bioRxiv · Jul 5, 2019Microbiology