S. K. Pillai

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency

This study identifies CD73 as a marker of HIV latency, showing hypoxia enhances its expression and adenosine signaling promotes viral quiescence.

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

This study shows that galectin-9 enhances SARS-CoV-2 replication and inflammation in airway epithelial cells by promoting viral entry and activating pro-inflammatory pathways.

μ-Lat: A Mouse Model to Evaluate Human Immunodeficiency Virus Eradication Strategies

The paper develops a humanized mouse model to evaluate HIV eradication strategies by transplanting J-Lat cells and testing TNF's effect on viral reactivation.

Durable Control of HIV-1 Using a Staphylococcus aureus Cas9-Expressing Lentivirus Co-Targeting Viral Latency and Host Susceptibility

This study develops a lentiviral vector targeting both HIV-1 provirus and host CXCR4 to reduce gene editing efficacy thresholds for an HIV-1 cure.

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

Chromatin Functional States Correlate with HIV Latency Reversal in Infected Primary CD4+ T Cells

The paper identifies that latency reversing agents reactivate less than 5% of latent HIV proviruses and shows distinct chromatin functional states between reactivated and non-reactivated cells.