B. Korber

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.2.86

This study evaluates the neutralization escape of the SARS-CoV-2 Omicron subvariant BA.2.86 compared to other variants, finding lower neutralization by antibodies than BA.2 but comparable to circulating variants.

Mutational basis of serum cross-neutralization profiles elicited by infection or vaccination with SARS-CoV-2 variants

The paper models cross-neutralization profiles of SARS-CoV-2 sera against variants by analyzing mutations and shows that a third dose of mRNA-1273 improves neutralization breadth.

Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters

This study evaluates the durability of humoral and cellular immune responses to XBB.1.5 after bivalent mRNA boosters, finding waning neutralizing antibody titers but preserved T cell responses.

Substantial Neutralization Escape by the SARS-CoV-2 Omicron Variant BQ.1.1

The paper shows BQ.1.1 SARS-CoV-2 variant has greater neutralization escape compared to BA.5, with lower NAb titers in vaccinated individuals.

Structural basis for breadth development in a HIV-1 neutralizing antibody

This paper determines structures of HIV-1 antibodies at different stages of maturation to understand how neutralization breadth develops through affinity optimization.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Structural diversity of the SARS-CoV-2 Omicron spike

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

This paper engineers HIV-1 envelope trimers with enhanced V2 and fusion peptide neutralization sensitivity for vaccine development.

The SARS-CoV-2 Spike Variant D614G Favors an Open Conformational State

This study shows the D614G mutation in SARS-CoV-2 Spike protein increases open conformations, enhancing infectivity and neutralization sensitivity.

Exploring the role of glycans in the interaction of SARS-CoV-2 RBD and human receptor ACE2

This study uses molecular simulations to analyze how different glycan types on SARS-CoV-2 RBD and ACE2 affect their binding, finding that glycan presence does not alter the contact signature but influences binding affinity.

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

This study shows that B.1.1.7 SARS-CoV-2 variant remains neutralizable by antibodies from ancestral Spike vaccines and convalescent sera, though with reduced efficacy.

Durable Control of HIV-1 Using a Staphylococcus aureus Cas9-Expressing Lentivirus Co-Targeting Viral Latency and Host Susceptibility

This study develops a lentiviral vector targeting both HIV-1 provirus and host CXCR4 to reduce gene editing efficacy thresholds for an HIV-1 cure.

Epigraph Hemagglutinin Vaccine Induces Broad Cross-reactive Immunity Against Swine H3 Influenza Virus

This study designs a universal swine H3 influenza vaccine using a computational algorithm called Epigraph, showing improved cross-reactive immunity in both mice and pigs compared to existing vaccines.

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

The paper identifies recombination and purifying selection in coronaviruses from different hosts as key factors in SARS-CoV-2 emergence.