Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation
W. Wang, A. Dernst, B. Martin, L. Lorenzi, K. Phulphagar, A. Wagener, C. Budden, N. Stair, T. Wagner, H. Faerber, A. Jaensch, R. Stahl, F. Duthie, S. V. Schmidt, R. C. Coll, , E. Latz
The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.
bioRxiv · Mar 26, 2024 · PreprintImmunology