Author

F. Duthie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

E. Latz· 2 shared M. S. J. Mangan· 2 shared A. Akbal· 1 shared A. Ashworth· 1 shared A. Dernst· 1 shared A. Gulati· 1 shared A. Jaensch· 1 shared A. Johns· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

E. Latz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation

M. S. J. Mangan, A. Akbal, S. Rivara, A. Schroeder, G. L. Horvath, P. Walch, J. Hegermann, R. Kaiser, F. Duthie, J. Selkrig, J. Jantsch, R. Gerhard, D. Wachten, E. Latz

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

bioRxiv · Mar 26, 2024 · PreprintImmunology

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

W. Wang, A. Dernst, B. Martin, L. Lorenzi, K. Phulphagar, A. Wagener, C. Budden, N. Stair, T. Wagner, H. Faerber, A. Jaensch, R. Stahl, F. Duthie, S. V. Schmidt, R. C. Coll, , E. Latz

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

bioRxiv · Mar 26, 2024 · PreprintImmunology

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

S. Dreyer, R. Upstill-Goddard, V. Paulus-Hock, C. Paris, E. Maria-Lampraki, E. Dray, B. Serrels, S. Rebus, H. Brunton, C. Nourse, U.-M. Bailey, M. Jones, K. Moran-Jones, D. Wright, F. Duthie, , Lord

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.

bioRxiv · Jul 24, 2019Cancer Biology