F. Meissner

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3-/- mice

The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.

Platelet-derived transcription factors license human monocyte 1 inflammation

This study shows platelets are crucial for human monocyte inflammation, as their absence causes immunoparalysis and their addition restores cytokine responses.

Dual perspective proteomics infectome profiling discovers Salmonella type III secretion system effector functions in macrophages

The paper uses proteomics to identify Salmonella type III secretion system effectors in macrophages and their role in virulence.

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

This study shows that amyloid-like aggregates impair lysosomal function in neurons by sequestering AP-31, leading to neurotoxicity.

Dietary intake regulates the circulating inflammatory monocyte pool

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

EASI-tag enables accurate multiplexed proteome quantification by generating interference-free reporter ions through dissociation at low collision energy.