Reduced insulin and IGF-1 signalling synergistically extend healthspan in male mice
A. M. N. Walker, N. T. Watt, N. Warmke, N. Y. Yuldasheva, M. Drozd, N. J. Haywood, A. Skromna, N. Makava, S. B. Wheatcroft, M. T. Kearney, R. M. Cubbon
This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.
bioRxiv · Mar 15, 2019 · PreprintCell Biology