Author

S. B. Wheatcroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

M. T. Kearney· 3 shared C. G. Myers· 2 shared C. W. Fishwick· 2 shared D. J. Beech· 2 shared H. Viswambharan· 2 shared K. Bridge· 2 shared K. J. Simmons· 2 shared L. Lunn· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

M. T. Kearney

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Author profile →

3 papers

Recent·Most cited

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. M. Clavane, D. J. Beech, R. M. Cubbon, S. B. Wheatcroft, M. J. McPhillie, T. Issad, C. W. Fishwick, , K. J. Simmons

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

bioRxiv · Mar 11, 2024Cell Biology

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

K. J. Simmons, C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. Clavane, D. J. Beech, R. Cubbon, S. B. Wheatcroft, M. J. McPhillie, C. W. Fishwick, M. T. Kearney

The paper identifies a small molecule that inhibits insulin receptor-insulin-like growth factor-1 receptor heterodimers, revealing their distinct physiological role in endothelial cells.

bioRxiv · Dec 9, 2021 · PreprintCell Biology

Reduced insulin and IGF-1 signalling synergistically extend healthspan in male mice

A. M. N. Walker, N. T. Watt, N. Warmke, N. Y. Yuldasheva, M. Drozd, N. J. Haywood, A. Skromna, N. Makava, S. B. Wheatcroft, M. T. Kearney, R. M. Cubbon

This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.

bioRxiv · Mar 15, 2019 · PreprintCell Biology