SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2
N. Taefehshokr, A. Lac, A. M. Vrieze, B. H. Dickson, P. N. Guo, C. Jung, E. N. Blythe, C. Fink, A. Aktar, J. D. Dikeakos, G. A. Dekaban, B. Heit
This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.
bioRxiv · Feb 10, 2023 · PreprintImmunology