C. Fink

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

This study uses mCherry-titin mice to visualize sarcomere dynamics during skeletal muscle development and injury repair, revealing titin mobility and localization patterns in myocytes.

FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

In vivo tracking of adenoviral-transduced iron oxide-labeled bone marrow-derived dendritic cells using magnetic particle imaging

This study uses magnetic particle imaging to track in vivo migration of iron oxide-labeled dendritic cells, showing improved quantification with a focused lymph node scan.

SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2

This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

An integrated systems-biology platform for power-to-gas technology

This paper develops a systems-biology platform for Methanothermobacter spp. to optimize power-to-gas technology by analyzing genome-scale metabolic models and growth performance in bioreactors.

The targeted deletion of genes responsible for expression of the Mth60 fimbriae leads to loss of cell-cell connections in M. thermautotrophicus ΔH

This study deletes genes encoding Mth60 fimbriae in M. thermautotrophicus ΔH, showing a loss of cell-cell connections and altered biofilm formation.

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

Magnetic Particle Imaging is a sensitive in vivo imaging modality for the quantification of dendritic cell migration

This study uses magnetic particle imaging to track and quantify dendritic cell migration in vivo, showing sensitivity of ~4000 cells and validating results with ex vivo MPI and histology.

A shuttle-vector system allows heterologous gene expression in the thermophilic methanogen Methanothermobacter thermautotrophicus ΔH

This paper develops a shuttle-vector system for genetic modification of Methanothermobacter thermautotrophicus, enabling heterologous gene expression and growth on alternative substrates.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.

Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

This study shows that balanced JAK/STAT signaling is essential for maintaining structural and functional homeostasis in Drosophila respiratory epithelia, while chronic overactivation leads to pathological changes resembling human lung diseases.