Author

J. D. Dikeakos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Assay:proteomics· 2

Frequent Co-Authors

C. Fink· 6 shared G. A. Dekaban· 6 shared B. Heit· 4 shared A. Finzi· 3 shared E. N. Pawlak· 3 shared G. Beaudoin-Bussieres· 3 shared J. Prevost· 3 shared H. Medjahed· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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6 shared papersImmunology

C. Fink

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

In vivo tracking of adenoviral-transduced iron oxide-labeled bone marrow-derived dendritic cells using magnetic particle imaging

C. Fink, J. J. Gevaert, J. W. Barrett, J. D. Dikeakos, P. J. Foster, G. A. Dekaban

This study uses magnetic particle imaging to track in vivo migration of iron oxide-labeled dendritic cells, showing improved quantification with a focused lymph node scan.

bioRxiv · Mar 14, 2023 · PreprintImmunology

SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2

N. Taefehshokr, A. Lac, A. M. Vrieze, B. H. Dickson, P. N. Guo, C. Jung, E. N. Blythe, C. Fink, A. Aktar, J. D. Dikeakos, G. A. Dekaban, B. Heit

This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.

bioRxiv · Feb 10, 2023 · PreprintImmunology

The Staphylococcus aureus iron-regulated surface determinant A (IsdA) increases SARS CoV-2 replication by modulating JAK-STAT signaling

M. I. Goncheva, R. Gibson, A. C. Shouldice, J. D. Dikeakos, D. E. Heinrichs

This paper shows that Staphylococcus aureus IsdA enhances SARS CoV-2 replication by modulating JAK-STAT signaling in co-infected cells.

bioRxiv · Jun 27, 2022 · PreprintMicrobiology

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

M. Benlarbi, G. Laroche, C. Fink, K. Fu, R. P. Mulloy, A. Phan, A. Ariana, C. M. Stewart, J. Prevost, G. Beaudoin-Bussieres, R. Daniel, Y. Bo, J. Yockell-Lelievre, W. L. Stanford, P. M. Giguere, , M. Cote

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

bioRxiv · Feb 19, 2022Microbiology

Magnetic Particle Imaging is a sensitive in vivo imaging modality for the quantification of dendritic cell migration

J. J. Gevaert, C. Fink, J. D. Dikeakos, G. A. Dekaban, P. J. Foster

This study uses magnetic particle imaging to track and quantify dendritic cell migration in vivo, showing sensitivity of ~4000 cells and validating results with ex vivo MPI and histology.

bioRxiv · Sep 22, 2021 · PreprintBiophysics

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

I. Ullah, J. Prevost, M. S. Ladinsky, H. Stone, M. Lu, S. P. Anand, G. Beaudoin-Bussieres, K. Symmes, M. Benlarbi, S. Ding, R. Gasser, C. Fink, Y. Chen, A. Tauzin, G. Goyette, , P. D. Uchil

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

bioRxiv · Mar 22, 2021Immunology

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

R. Gasser, M. Cloutier, J. Prevost, C. Fink, E. Ducas, S. Ding, N. Dussault, P. Landry, T. Tremblay, A. Laforce-Lavoie, A. Lewin, G. Beaudoin-Bussieres, A. Laumaea, H. Medjahed, C. Larochelle, , A. Finzi

This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.

bioRxiv · Oct 9, 2020Microbiology

GATA2 Expression by Intima-Infiltrating Macrophages Drives Early Atheroma Formation

C. Yin, A. M. Vreize, J. Akingbasote, E. N. Pawlak, R. A. Jacob, J. Hu, N. Sharma, J. D. Dikeakos, L. Barra, A. D. Nagpal, B. Heit

The paper identifies GATA2 overexpression in early-stage atherosclerotic macrophages as a driver of functional defects linked to atheroma formation.

bioRxiv · Jul 26, 2019 · PreprintImmunology

PACS-1 and Adaptor Protein-1 Mediate ACTH Trafficking to the Regulated Secretory Pathway

B. S. Dirk, C. End, E. N. Pawlak, L. R. Van Nynatten, R. A. Jacob, B. Heit, J. D. Dikeakos

This study identifies PACS-1 and AP-1 as essential for directing POMC to DCSGs, as their knockdown prevents POMC from being trafficked to these granules.

bioRxiv · Oct 17, 2018Cell Biology

Soluble CD93 is an Apoptotic Cell Opsonin Recognized by the αxβ2 Integrin

J. W. D. Blackburn, D. H. C. Lau, J. Ellins, A. Kipp, E. N. Pawlak, J. D. Dikeakos, B. Heit

This study identifies soluble CD93 as an opsonin recognized by αxβ2 integrin for efferocytosis, showing membrane-bound CD93 lacks efferocytic activity.

bioRxiv · Jun 7, 2018Immunology