G. A. Dekaban

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and Activation

This study identifies a MERTK-integrin signaling pathway that coordinates efferocytosis by regulating integrin localization and activation.

In vivo tracking of adenoviral-transduced iron oxide-labeled bone marrow-derived dendritic cells using magnetic particle imaging

This study uses magnetic particle imaging to track in vivo migration of iron oxide-labeled dendritic cells, showing improved quantification with a focused lymph node scan.

SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2

This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

Magnetic Particle Imaging is a sensitive in vivo imaging modality for the quantification of dendritic cell migration

This study uses magnetic particle imaging to track and quantify dendritic cell migration in vivo, showing sensitivity of ~4000 cells and validating results with ex vivo MPI and histology.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.