Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease
N. KANESHIRO, K. MASATO, R. IMAOKA, A. IKEDA, Y. KAMIKUBO, T. HASHIMOTO, T. IWATSUBO, T. SAKURAI, T. UEHARA, N. TAKASUGI
This study identifies lipid flippase dysfunction as a key pathogenic event in Alzheimer's disease and presents a peptide therapy to restore endosomal function.
bioRxiv · Jul 30, 2021Biochemistry