T. Hashimoto

Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

This study identifies an antibody, CV804, that targets the conserved S2 domain of coronaviruses and shows broad cross-reactivity and ADCC activity against SARS-CoV-2 and related viruses.

Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer

This study shows that androgen receptor inhibition in prostate cancer cells shifts metabolism to oxidative mitochondrial pathways and increases sensitivity to complex I inhibitors.

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.

Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids

This study introduces a Microwell Flow Device that improves spheroid viability and drug response in prostate cancer models by reducing hypoxia-related necrosis.

Phylogenomics invokes the clade housing Cryptista, Archaeplastida, and Microheliella maris.

This study clarifies the phylogenetic position of Microheliella maris, placing it as a basal lineage of Cryptista and proposing a new clade Pancryptista, which includes Archaeplastida and M. maris.

Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease

This study identifies lipid flippase dysfunction as a key pathogenic event in Alzheimer's disease and presents a peptide therapy to restore endosomal function.

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

This study compares the composition of normal stress granules and mutant FUS assemblies in stressed cells, identifying molecular differences and their impact on cellular stress responses in ALS-FUS.

Evaluating the tea bag method as a potential tool for detecting the effects of added nutrients and their interactions with climate on litter decomposition

This study evaluates the tea bag method's ability to detect nutrient addition effects and their interaction with climate on litter decomposition, finding it effective for early-stage but not late-stage decomposition.

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

Perception of and anxiety about COVID-19 infection and risk behaviors for spreading infection: An international comparison

This study compares public perception, anxiety, and risk behaviors related to COVID-19 across Japan, the UK, and Spain using survey data.

Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate

This study reveals that T and B lymphocyte populations increase in the mouse prostate between 6 and 12 months of age, indicating age-related inflammation kinetics in the prostate.

Functional analysis of the chromosomal passenger complex in Arabidopsis

This study identifies and characterizes a Borealin homolog in Arabidopsis, supporting the existence of a chromosome passenger complex in plants.

Barthelonids represent a deep-branching Metamonad clade with mitochondrion-related organelles generating no ATP.

This study determines the phylogenetic position of barthelonids and reveals their mitochondrion-related organelles lack ATP-generating capacity.

Elucidating the activation mechanisms for bifurcation of regulatory and effector T cell fates by multidimensional single cell analysis

This study uses single-cell RNA-seq and multidimensional analysis to show how TCR signals control the activation and differentiation of regulatory and effector T cells.

Phylogenomics places orphan protistan lineages in a novel eukaryotic super-group

The paper uses phylogenomic analysis to place orphan protist lineages into a novel eukaryotic super-group, CRuMs, and clarifies their relationship to Amorphea.