Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging
C. Rosselot, A. Alvarsson, P. Wang, Y. Li, K. Beliard, G. Lu, R. Li, H. Liu, V. Gillespie, N. Tzavaras, K. Kumar, R. J. DeVita, A. F. Stewart, S. A. Stanley, A. Garcia-Ocana
This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.
bioRxiv · Jul 24, 2020 · PreprintCell Biology