S. A. Stanley

Alternating Magnetic Fields Drive Stimulation of Gene Expression via Generation of Reactive Oxygen Species

This study identifies reactive oxygen species (ROS) generation as a key mechanism by which alternating magnetic fields stimulate gene expression via TRPV1 activation.

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

Magnetogenetic cell activation using endogenous ferritin

This paper develops a magnetogenetic method using anti-ferritin nanobodies and a benchtop electromagnet to activate cells in vivo, improving glucose tolerance in mice.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

This study identifies GM-CSF and HIF-1 activation as IFN-γ-independent mechanisms by which CD4 T cells control M. tuberculosis infection.

Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2

This study screens FDA-approved compounds for antiviral activity against SARS-CoV-2 and identifies 13 effective compounds, including seven new candidates and one synergistic combination with remdesivir.

Mammary ductal epithelium controls cold-induced adipocyte thermogenesis

The paper shows that mammary ductal epithelial cells regulate cold-induced adipocyte thermogenesis via secreted factors called mammokines in female mice.

Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

Repeated hypoglycemia blunts the responsiveness of glucose-inhibited GHRH neurons by remodeling neural inputs and disrupting mitochondrial structure and function.

This study shows repeated hypoglycemia reduces GHRH neuron responsiveness by altering neural inputs and mitochondrial function, suggesting mitochondrial dynamics as a target for preventing hypoglycemia unawareness.