C. Rosselot

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile

This study compares scRNA-seq and snRNA-seq of human pancreatic islets, identifying new gene markers and three β-cell subpopulations with distinct transcriptional profiles.

Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant.

This study investigates the impact of a GIPR variant on glucose homeostasis using a mouse model, finding altered intracellular trafficking and increased GIP sensitivity.