Author

N. Vuksanovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

N. R. Silvaggi· 4 shared D. A. Serrano· 2 shared D. Frick· 2 shared R. S. Virdi· 2 shared A. Majumder· 1 shared A. W. Schwabacher· 1 shared B. Imperiali· 1 shared B. R. Patterson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersBiochemistry

N. R. Silvaggi

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5 papers

Recent·Most cited

Synergistic computational and experimental studies of a phosphoglycosyltransferase membrane/ligand ensemble

A. Majumder, N. Vuksanovic, L. C. Ray, H. M. Bernstein, K. N. Allen, B. Imperiali, J. E. Straub

This study combines computational and experimental approaches to investigate the interaction of undecaprenol phosphate with the phosphoglycosyltransferase PglC from Campylobacter, revealing insights into substrate recognition and binding mechanisms.

bioRxiv · May 7, 2023Biochemistry

Structural and Preliminary Biochemical Characterization of MppQ, a PLP-Dependent Aminotransferase from Streptomyces hygroscopicus

N. Vuksanovic, D. A. Serrano, A. W. Schwabacher, N. R. Silvaggi

This study characterizes MppQ, a PLP-dependent aminotransferase from Streptomyces hygroscopicus, revealing its structure and function in L-enduracididine biosynthesis.

bioRxiv · Apr 3, 2022 · PreprintBiochemistry

Engineering a more specific E. coli glyoxylate/hydroxypyruvate reductase for coupled steady state kinetics assays

N. Vuksanovic, D. A. Serrano, B. R. Patterson, N. R. Silvaggi

The paper engineers a more specific variant of E. coli glyoxylate/hydroxypyruvate reductase (EcGhrA) to improve its use as a coupling enzyme for monitoring aminotransferase activity.

bioRxiv · Apr 2, 2022 · PreprintBiochemistry

Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3

R. S. Virdi, R. V. Bavisotto, N. C. Hopper, N. Vuksanovic, T. R. Melkonian, N. R. Silvaggi, D. Frick

The paper identifies potential ligands for the SARS-CoV-2 Nsp3 Mac1 domain using a high-throughput DSF assay and validates them with molecular docking and structural analysis.

bioRxiv · Jul 6, 2020Biochemistry

Molecular Basis for ADP-ribose Binding to the Macro-X Domain of SARS-CoV-2 Nsp3

D. Frick, R. S. Virdi, N. Vuksanovic, N. Dahal, N. R. Silvaggi

This study investigates the ADP-ribose binding capability of the SARS-CoV-2 nsp3 macrodomain, revealing its structural conservation despite sequence divergence from other coronaviruses.

bioRxiv · Mar 31, 2020Biochemistry