Hypoxia induced carbonic anhydrase mediated dorsal horn sensory neuron activation and induction ofneuropathic pain
Marlene E. Da Vitoria Lobo, N. Weir, Lydia D. Hardowar, Yara Al Ojaimi, R. Madden, Alex Gibson, Samuel M. Bestall, Chris B. Schaffer, Masanori Hirashima, Lucy Frances Donaldson, David O. Bates, Richard P. Hulse
The paper shows that hypoxia in the spinal dorsal horn, caused by vascular issues, activates sensory neurons and leads to neuropathic pain, which can be reversed by inhibiting carbonic anhydrase.
bioRxiv · Jun 8, 2021 · PreprintNeuroscience