Dose and sex-specificity in Canagliflozin-mediated neuroprotection in aging mice
Dulmalika Herath Manchanayake, Hashan S. M. Jayarathne, Sydney Scofield, Naduni Dasanthi Hitihami Mudiyanselage, Lindsey M. DeHaan, Omar Kadri, Nabeelah Rouf, Brett C. Ginsburg, Richard A. Miller, Marianna Sadagurski
This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.
bioRxiv · Jul 8, 2026 · PreprintNeuroscience