Hashan S. M. Jayarathne

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.

This study investigates how canagliflozin affects brain aging and Alzheimer's-like pathology in mice, finding sex-specific effects on hippocampal function and disease markers.

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

This study shows that prenatal benzene exposure alters hypothalamic development in male offspring, leading to metabolic dysregulation and increased susceptibility to metabolic disease later in life.

This study shows that Canagliflozin improves central insulin sensitivity and reduces neuroinflammation in aged male mice but not females, suggesting sex-specific neuroprotective effects.

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.