Marianna Sadagurski

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.

This study investigates how canagliflozin affects brain aging and Alzheimer's-like pathology in mice, finding sex-specific effects on hippocampal function and disease markers.

This study investigates the metabolic effects of low-dose benzene exposure in mice, finding mitochondrial dysfunction and dose-dependent changes in metabolic pathways.

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

This study shows that prenatal benzene exposure alters hypothalamic development in male offspring, leading to metabolic dysregulation and increased susceptibility to metabolic disease later in life.

This study shows that GHR in AgRP neurons affects thermogenesis in aged mice, with sex-specific differences in body temperature and BAT gene expression.

This study shows that Canagliflozin improves central insulin sensitivity and reduces neuroinflammation in aged male mice but not females, suggesting sex-specific neuroprotective effects.

This study identifies GHR-expressing neurons in the hypothalamic arcuate nucleus that regulate glucose metabolism and energy homeostasis through GH activation.

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.