Sydney Scofield

Dose and sex-specificity in Canagliflozin-mediated neuroprotection in aging mice

This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.

Integrative multiomics analysis of metabolic dysregulation induced by occupational benzene exposure in mice

This study investigates the metabolic effects of low-dose benzene exposure in mice, finding mitochondrial dysfunction and dose-dependent changes in metabolic pathways.

Hypothalamic Sex-Specific Metabolic Shift by Canagliflozin during Aging

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

Microglial NF-κB Signaling Deficiency Protects Against Metabolic Disruptions Caused by Volatile Organic Compound via Modulating the Hypothalamic Transcriptome

Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life

This study shows that prenatal benzene exposure alters hypothalamic development in male offspring, leading to metabolic dysregulation and increased susceptibility to metabolic disease later in life.