Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation
Emma Danhash, Anthony C. Verbeck, Daniel Western, Andrea S. Díaz‐Pacheco, Grant Galasso, Shih‐Feng You, Guangming Huang, Emma Starr, Nadia Miller, Collin J. Nadarajah, Savannah J Tiemann, Erik S. Musiek, Jasmin Herz, Abhirami Kannan Iyer, John R. Cirrito, , Celeste M M. Karch
This study shows that Ms4a4a deficiency reduces amyloid beta pathology in mice by enhancing Aβ clearance, supported by increased MMP-9 production in microglia and human CSF data.
Alzheimer s & Dementia · Aug 1, 2025Peer-reviewedNeuroscience