John R. Cirrito

This study investigates hippocampal network dysfunction in a Wolfram syndrome mouse model, finding hyperexcitable neurons without seizures or increased network bursting.

This study shows that Ms4a4a deficiency reduces amyloid beta pathology in mice by enhancing Aβ clearance, supported by increased MMP-9 production in microglia and human CSF data.

This study identifies heterozygous lysosomal enzyme gene mutations as risk factors for Alzheimer's disease and validates their impact on amyloid-beta processing using mouse models.

This paper develops microimmunoelectrodes for electrochemical detection of dynorphin, showing sensitivity in the attomolar range and selectivity over other opioids.