Dosing and Serostatus Shape the Efficacy of Adenovirus, mRNA, and Protein Vaccines
Bakare Awakoaiye, Shiyi Li, Sarah Sanchez, Tanushree Dangi, Nahid Irani, Laura Arroyo, Gabriel Arellano, Shadi Mohammadabadi, Malika Aïd, Pablo Penaloza‐MacMaster
This study compares the immunological profiles and protective efficacy of Ad5, mRNA, and protein vaccines in mice, showing differences in antigen kinetics, immune responses, and performance based on serostatus and dosing regimen.
bioRxiv · Jul 16, 2025 · PreprintImmunology