Pablo Penaloza‐MacMaster

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

Development of a cross-protective common cold coronavirus vaccine

This paper develops an mRNA vaccine against OC43, a common cold coronavirus, showing cross-protection against related viruses like MHV-A59.

Dosing and Serostatus Shape the Efficacy of Adenovirus, mRNA, and Protein Vaccines

This study compares the immunological profiles and protective efficacy of Ad5, mRNA, and protein vaccines in mice, showing differences in antigen kinetics, immune responses, and performance based on serostatus and dosing regimen.

Effects of protein boosters on antibody responses

This study compares antibody responses after homologous and heterologous boosting in mice, finding that protein-based boosters elicit stronger antibody responses than Ad5-based boosters.

A single-cell atlas reveals shared and distinct immune responses and metabolism during SARS-CoV-2 and HIV-1 infections

This study compares immune responses and metabolism in SARS-CoV-2 and HIV-1 infections using single-cell transcriptomics, identifying shared and distinct features in 94,442 PBMCs from 16 patients.