TRMT6/61A-mediated m1A methylation facilitates human pre-tRNA maturation and prevents surveillance by XRN2
Xisheng Liu, Nhi Yen Tran Nguyen, Abigail Grace Johnston, Ilias Skeparnias, Monima Anam, Katie Marlow, Naira Rehman, Andrew H. Kellum, Yinsheng Wang, Jinwei Zhang, Zhangli Su
This study shows TRMT6/61A-mediated m1A methylation on pre-tRNAs is essential for their maturation and prevents XRN2-mediated degradation, maintaining translational homeostasis.
bioRxiv · May 19, 2026 · PreprintGenetics