Zhangli Su

The paper uses Nanopore and Illumina sequencing to study age-related changes in yeast tRNA modifications and CCA-tail dynamics.

This study shows temozolomide causes RNA alkylation and widespread translational repression in glioblastoma cells by targeting guanine-rich transcripts.

This study identifies 5'-tRNA halves (tiR5s) as markers of poor prognosis and therapeutic resistance in glioblastoma, linking them to disease persistence and invasive pathways.

The paper identifies tRF-3021a as a cancer-promoting tRNA-derived fragment that supports invasiveness, apoptosis resistance, and global protein synthesis in cancer cell lines.

PATTY corrects open chromatin bias in CUT&Tag data using ATAC-seq and machine learning, improving detection of histone modifications and cell clustering in single-cell analyses.

This study shows TRMT6/61A-mediated m1A methylation on pre-tRNAs is essential for their maturation and prevents XRN2-mediated degradation, maintaining translational homeostasis.

The paper identifies small RNA biomarkers, including tRFs and miRNAs, associated with IRI and EAD in liver transplantation using tissue and perfusate samples.

This study investigates the role of ORC2 in epigenetic regulation and chromosome structure through a multi-omics analysis of a human cell line with ORC mutations.

The paper analyzes DNA replication origins and ORC/MCM binding sites in human cells, finding minimal overlap and suggesting origins are specified by stochastic events rather than specific binding sites.

tRForest improves tRNA fragment target prediction using random forest, validated in cell lines and showing enrichment in neuronal function.

The paper shows that ATAC-seq can detect thousands of extrachromosomal circular DNAs in cancer and cell lines without specific enrichment.

The paper shows that the miR-206 family is not essential for myogenesis in vitro but affects mitochondrial function and muscle performance in vivo.

The paper identifies prognostic germline variants in 10,582 cancer patients using multivariate Cox regression, showing their association with patient outcomes beyond clinical data.

The paper examines tRNA-derived fragments (tRFs) and microRNAs in the maternal-fetal interface of a mouse model to assess their expression patterns and response to maternal immune activation.

This study shows ANG cleaves specific tRNAs to produce halves and tRF-5s, but stress-induced tRNA halves are mostly ANG-independent, and tRF-3s are not generated from tRNA halves or ANG cleavage.

The paper identifies tRF-3 fragments that repress gene expression through Argonaute-dependent seed sequence matching, independent of Dicer.