The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons
Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
This study investigates how aging and oxidative stress interact in Huntington disease neurons from mice and humans, finding that aging accelerates mutant HTT accumulation and increases oxidative stress sensitivity.
Frontiers in Aging Neuroscience · Sep 18, 2020Peer-reviewedNeuroscience