Phosphatidylinositol 3-phosphate promotes 53BP1 condensate-like assembly at DNA double-strand breaks
Nan Xiong, Gaofeng Cui, Xuanqi Xu, Yawen Xie, Shih-Chieh Ti, Shikang Liang, Viji M. Draviam, Yang Liu, Cheng‐han Yu, Georges Mer, Michael S.Y. Huen
This study identifies PI(3)P binding to the 53BP1 tBRCT domain as essential for promoting 53BP1 condensate-like assembly at DNA double-strand breaks.
bioRxiv · May 16, 2026 · PreprintCell Biology