Neurosciencenpj Parkinson s DiseasePeer-reviewed
Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation
Quyen Do, Humaira Noor, Ricardo Márquez-Gómez…·Richard Wade‐Martins
This study shows that the GBA-N370S mutation causes early hyperexcitability in striatal neurons by reducing sodium and potassium currents, which can be mitigated by aging or PKA antagonism.
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