Author

Bryan Ng

University of OxfordORCID 0000-0002-6819-0176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Richard Wade‐MartinsiD· 4 shared Ajantha S AbeyiD· 2 shared Alan J. ThomasiD· 2 shared Anne HedegaardiD· 2 shared Basil H. RidhaiD· 2 shared Dayne A. Beccano-KellyiD· 2 shared Dennis ChaniD· 2 shared Ece KocagöncüiD· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Richard Wade‐MartinsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation

Quyen Do, Humaira Noor, Ricardo Márquez-Gómez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha S Abey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne A. Beccano-Kelly, Jimena Baleriola, Nora Bengoa‐Vergniory, Richard Wade‐Martins

This study shows that the GBA-N370S mutation causes early hyperexcitability in striatal neurons by reducing sodium and potassium currents, which can be mitigated by aging or PKA antagonism.

npj Parkinson s Disease · Apr 12, 2024Peer-reviewedNeuroscience

Tau depletion in human neurons mitigates A beta-driven toxicity

Bryan Ng, Jane Vowles, Féodora L. Bertherat, Ajantha S Abey, Peter Kilfeather, Dayne A. Beccano-Kelly, M. Irina Stefana, Darragh Patrick O'Brien, Nora Bengoa‐Vergniory, Phillippa J. Carling, John A. Todd, Tara M. Caffrey, Natalie Connor‐Robson, Sally A. Cowley, Richard Wade‐Martins

This study shows that reducing tau in human neurons decreases A beta toxicity, supporting the role of tau in Alzheimer's disease mechanisms.

Molecular Psychiatry · Feb 15, 2024Peer-reviewedNeuroscience

iPSC-Astrocyte morphology reflects patient clinical markers

Helen A. Rowland, Georgina Miller, Qiang Liu, Nicola R Sharp, Bryan Ng, Liting Wei, Kanisa Arunasalam, Ivan G. Koychev, Anne Hedegaard, Elena M. Ribé, Dennis Chan, Tharani Chessell, Ece Kocagöncü, Jennifer Lawson, Paresh Malhotra, , Noel J. Buckley

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

bioRxiv · Jul 15, 2023 · PreprintNeuroscience

Neurons from individual early Alzheimer's disease patients reflect clinical vulnerability

Bryan Ng, Helen A Rowland, Liting Wei, Kanisa Arunasalam, Emma Mee Hayes, Ivan G. Koychev, Anne Hedegaard, Elena M. Ribé, Dennis Chan, Tharani Chessell, Dominic H Ffytche, Roger N. Gunn, Ece Kocagöncü, Jennifer Lawson, Paresh Malhotra, , Richard Wade‐Martins

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

Brain Communications · Oct 20, 2022Peer-reviewedNeuroscience