TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob A. C. Keen, Soher Nagi Jayash, Natalie Crump, Lucinda Evans, Maya Karmali, Worachet Promruk, Claire Elizabeth Clarkin, Sonoko Narisawa, Louise A. Stephen, Brian Lee Foster, Prof. José Luis Millán, Colin Farquharson, Katherine Ann Staines
This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.
bioRxiv · Feb 26, 2026 · PreprintDevelopmental Biology