Colin Farquharson

A frameshift mutation in PRICKLE1 causes skeletal dysplasia in Cheviot sheep

The paper identifies a 10 bp deletion in PRICKLE1 causing skeletal dysplasia in Cheviot sheep and develops a DNA test to eliminate the mutation.

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton

This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.

Polyanionic Non-Collagenous Proteins and Their Analogues Promote Artificial Mineralization of Embryonic Mouse Bone

This study shows that polyanionic NCPs and their analogues promote artificial mineralization in embryonic mouse bone ECM by facilitating apatite infiltration into collagen fibrils.

Proteomic characterisation of matrix vesicles from primary osteoblasts indicates a mixed population with both exosomal and ectosomal routes of biogenesis.

This study characterizes the proteome of matrix vesicles from primary osteoblasts, revealing a heterogeneous population with features of both exosomal and ectosomal biogenesis.

Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

This study shows that increased PHOSPHO1 expression in renal osteodystrophy contributes to increased cortical bone mineral density but decreased trabecular bone density.

Ubiquitin-protein ligase Ubr5 cooperates with Hedgehog signalling to promote skeletal tissue homeostasis

This study shows UBR5 interacts with the HH pathway to regulate skeletal homeostasis and identifies potential targets for biomedical applications.