Aikta Sharma

Revealing multiscale architecture of the intact human spine using hierarchical phase contrast tomography

This paper uses HiP-CT to image the human spine at high resolution, revealing multiscale anatomy and microstructural features without exogenous contrast.

Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis

This study shows that microarchitectural features of articular calcified cartilage in mice predict abnormal strain distributions in osteoarthritis.

Optimising digital volume correlation across materials: a practical framework for accuracy and spatial resolution

This paper optimizes digital volume correlation (DVC) for multi-material biological tissues by evaluating image processing parameters and demonstrating a framework for accurate strain measurement across different tissue types.

Bridging the microstructural gap in human connectomics using hierarchical phase-contrast tomography as a reference for diffusion MRI in the human brain

This paper uses HiP-CT to image microstructural fiber orientations in the human brain, showing greater complexity than dMRI while being non-destructive.

Synchrotron Tomography-Based Inversion Pipeline for Estimating Elastic Properties of Rat Vertebral Endplate Finite Element Models

This paper develops an inversion pipeline using synchrotron tomography and digital volume correlation to estimate elastic properties of rat vertebral endplates, showing high spatial agreement between FEM predictions and experimental data.

Sex differences in osteoblast matrix maturation regulate osteoblast-endothelial interactions

This study shows sex differences in osteoblast (OB) extracellular matrix (ECM) composition influence vascular endothelial cell behavior through contact-dependent mechanisms.

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton

This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.

Regulation and function of trans-physeal growth plate bridges: evidence for a mechanical base isolation role to minimise epiphyseal shear stress

This study investigates the regulation and function of trans-physeal growth plate bridges in mice, finding they serve a mechanical role to reduce epiphyseal shear stress during bone growth.

In situ profiling of nanoscale displacements uncovers mechano-architectural predictors of osteoarthritis emergence

This study uses imaging and modeling to show how structural changes in knee joints predict osteoarthritis onset by altering strain distribution.

Multimodal imaging reveals multiscale mechanical interplay in vertebral endplate microarchitecture during intervertebral disc loading

This study uses multimodal imaging to examine mechanical strain and microarchitecture in vertebral endplates during intervertebral disc loading, revealing multiscale structural adaptations.

Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images

This paper uses persistent homology to analyze bone microstructure in non-linear microscopy images, showing significant differences between pathological and healthy samples.