Katherine Ann Staines

The paper identifies a 10 bp deletion in PRICKLE1 causing skeletal dysplasia in Cheviot sheep and develops a DNA test to eliminate the mutation.

This study shows that microarchitectural features of articular calcified cartilage in mice predict abnormal strain distributions in osteoarthritis.

This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.

This study investigates the regulation and function of trans-physeal growth plate bridges in mice, finding they serve a mechanical role to reduce epiphyseal shear stress during bone growth.

This study uses imaging and modeling to show how structural changes in knee joints predict osteoarthritis onset by altering strain distribution.

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

This study investigates the sex-specific effects of prenatal alcohol exposure on the murine skeleton, finding divergent impacts on bone formation, trabecular structure, and cortical bone parameters between male and female mice.

This study shows that increased PHOSPHO1 expression in renal osteodystrophy contributes to increased cortical bone mineral density but decreased trabecular bone density.

This study shows UBR5 interacts with the HH pathway to regulate skeletal homeostasis and identifies potential targets for biomedical applications.