Ongoing lymphoid HIV production drives pyroptosis and GLP-1 counter-regulation in ART-suppressed infection
Peter A Crawford, Joshua Rhein, Jeffrey G. Chipman, Gregory J. Beilman, Ross T. Cromarty, Kevin Escandón-Vargas, Jodi L. Anderson, Garritt Wieking, Andrew Johnston, Afeefa Ahmed, Jarrett Reichel, Alexander Khoruts, Christopher M. Basting, Nataliia Kuchma, Jason V. Baker, , Timothy W. Schacker
The paper shows that residual HIV production in lymph nodes of ART-suppressed individuals drives pyroptosis and is counter-regulated by GLP-1 upregulation in the ileum.
bioRxiv · Jan 10, 2026 · PreprintMicrobiology