A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing
Marella D. Canny, Leo C.K. Wan, Amélie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M. Noordermeer, Marcus D. Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F. Ng, Sachdev S. Sidhu, , Daniel Durocher
This paper develops a genetically encoded inhibitor of 53BP1, i53, which enhances homology-based gene editing by blocking NHEJ and promoting HR in non-replicating cells.
bioRxiv · Jun 28, 2016 · PreprintMolecular Biology