Author

Timothy F. Ng

Mount Sinai Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel DurocheriD· 2 shared Alexander van OudenaardeniD· 1 shared Alexandre Orthwein· 1 shared Amélie Fradet-Turcotte· 1 shared Andreas Ernst· 1 shared Andrew Vorobyov· 1 shared Clara BonnetiD· 1 shared Daniëlle Bianchi· 1 shared

Activity by Year

2016-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Daniel DurocherORCID

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2 papers

Recent·Most cited

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael A. VanInsberghe, Marieke Everts, Femke J. Bakker, H. Rudolf de Boer, Nathalie Moatti, Nicole Hustedt, Jay Z. Yin, Lisa Hoeg, Matthew Leibovitch, , Marcel A.T.M. van Vugt

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

Nature Communications · Nov 24, 2025Peer-reviewedCancer Biology

A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing

Marella D. Canny, Leo C.K. Wan, Amélie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M. Noordermeer, Marcus D. Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F. Ng, Sachdev S. Sidhu, , Daniel Durocher

This paper develops a genetically encoded inhibitor of 53BP1, i53, which enhances homology-based gene editing by blocking NHEJ and promoting HR in non-replicating cells.

bioRxiv · Jun 28, 2016 · PreprintMolecular Biology