Author

Alexandre Orthwein

Primary ORCID profile (0000-0002-7350-3413 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Alexandre OrthweiniD2 papers · Jewish General Hospital

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Amélie Fradet-Turcotte· 1 shared Andreas Ernst· 1 shared Andrew Vorobyov· 1 shared Daniel DurocheriD· 1 shared Frank Sicheri· 1 shared Leo C.K. Wan· 1 shared Marcus D. Wilson· 1 shared Marella D. Canny· 1 shared

Activity by Year

2016-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Amélie Fradet-Turcotte

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1 paper

Recent·Most cited

A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing

Marella D. Canny, Leo C.K. Wan, Amélie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M. Noordermeer, Marcus D. Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F. Ng, Sachdev S. Sidhu, , Daniel Durocher

This paper develops a genetically encoded inhibitor of 53BP1, i53, which enhances homology-based gene editing by blocking NHEJ and promoting HR in non-replicating cells.

bioRxiv · Jun 28, 2016 · PreprintMolecular Biology