The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer
Kruttika Dabke, Nicole Gull, Simion D. Kreimer, Pei-Chen Peng, Michael Diaz, Bassem Ben Cheikh, Amisha Dhawan, Katrina Evans, Nathan D. Ng, Xioapu Yuan, B.J. Rimel, Andrew John Li, Beth Y. Karlan, Simon Knott, Simon A. Gayther, , Michelle R. Jones
This study profiles the proteome of ovarian cancer tumors before and after chemotherapy, revealing how HRD status affects immune pathways and identifies potential therapeutic targets.
bioRxiv · Jun 1, 2025 · PreprintCancer Biology