Abhinav P. Acharya

Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models

The paper develops two strategies to increase mesaconate levels in the gut to reduce inflammation in Crohn's Disease mouse models.

Polymer of methyl malonic acid suppress inflammation by downregulating IL-2 through ROS overproduction

This paper develops a polymer, 1,6 MMA, that suppresses inflammation by reducing IL-2 and increasing mitochondrial ROS in T cells, showing therapeutic potential in collagen-induced arthritis.

Vaccines for immunological defense against traumatic brain injury

This paper develops a vaccine formulation to reduce inflammation after traumatic brain injury by inducing immunosuppressive cells and improving motor function in mice.

Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation

This paper develops itaconate polymer microparticles for intracellular delivery of itaconate to regulate macrophage inflammation, showing reduced cytotoxicity and metabolic changes.