Author

Nathaniel Islas

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

San JewelliD· 2 shared Yoseph BarashiD· 2 shared Alli JimeneziD· 1 shared Anupama JhaiD· 1 shared Bryan B. GuzmániD· 1 shared Caleb M. RadensiD· 1 shared Daniel DomingueziD· 1 shared Danielle GutmaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

San JewellORCID

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2 papers

Recent·Most cited

G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data

Farica Zhuang, Danielle Gutman, Nathaniel Islas, Bryan B. Guzmán, Alli Jimenez, San Jewell, Nicholas J. Hand, Katherine L. Nathanson, Daniel Dominguez, Yoseph Barash

G4mer identifies G-quadruplexes and disease variants from population-scale genetic data, improving accuracy and highlighting sequence features affecting rG4 formation.

Nature Communications · Nov 20, 2025Peer-reviewedGenetics

Machine learning-optimized targeted detection of alternative splicing

Kevin Yang, Nathaniel Islas, San Jewell, Di Wu, Anupama Jha, Caleb M. Radens, Jeffrey A. Pleiss, Kristen W. Lynch, Yoseph Barash, Peter S. Choi

This paper introduces LSV-seq, a targeted RNA-seq method optimized with machine learning to detect alternative splicing with high sensitivity and low sequencing depth.

Nucleic Acids Research · Dec 10, 2024Peer-reviewedGenomics