Bryan B. Guzmán

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

G4mer identifies G-quadruplexes and disease variants from population-scale genetic data, improving accuracy and highlighting sequence features affecting rG4 formation.

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

This study shows TDP-43 inhibits RNA accumulation in neurites by modulating RNA stability, with ALS mutations causing similar mislocalization.

This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.