Daniel Dominguez

Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

Massively parallel characterization of RNA G-quadruplex stability and molecular recognition

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

Robust mammalian RNA localization elements are complex and multipartite

The paper identifies that mammalian RNA localization elements are large, complex, and multipartite, requiring specific subsequences for function.

Sequence and structure of protein binding sites in RNA impact biomolecular condensates

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data

G4mer identifies G-quadruplexes and disease variants from population-scale genetic data, improving accuracy and highlighting sequence features affecting rG4 formation.

Charting the Multi-level Molecular Response to Palbociclib in ER-Positive Breast Cancer

This study identifies multi-level molecular changes in ER-positive breast cancer cells treated with palbociclib, revealing feedback loops and alternative splicing that suggest new therapeutic strategies.

The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

Dissecting RNA Selectivity Mediated by Tandem RNA-Binding Domains

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability

This study shows TDP-43 inhibits RNA accumulation in neurites by modulating RNA stability, with ALS mutations causing similar mislocalization.

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

Iron-sensitive RNA regulation by poly C binding proteins

The paper identifies iron-sensitive RNA regulation by poly C binding proteins through transcriptome analysis under low iron conditions.

Multi-omics analysis of multiple glucose-sensing receptor systems in yeast

This study compares two glucose receptor systems in yeast, showing they regulate distinct metabolic processes and signaling pathways.

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1

This paper investigates the roles of G protein subunits Gpa2 and Asc1/RACK1 in glucose signaling using transcriptomics and metabolomics in yeast, finding distinct contributions to sugar and amino acid metabolism.

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex sequences

This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.