Jie Wu

This study compares the effects of HTT knockout and CAG repeat expansion in cortical neurons, identifying shared and distinct biological pathways involved in HD.

This study shows that UHRF1 is essential for retinoblastoma progression by promoting oncogenic transcription, chromatin accessibility, and immune microenvironment shaping, but not tumor initiation.

This paper introduces EpiOut, a tool to detect chromatin accessibility outliers in ALS, showing they correlate with gene expression and protein level aberrations.

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

UFold predicts RNA secondary structures using deep learning, outperforming thermodynamic models and other learning-based methods with high accuracy and speed.

SAILER improves scATAC-seq analysis by learning invariant representations, enhancing clustering and imputation while scaling to large datasets.

The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.

This study compares 3-DGE and conventional mRNAseq, finding similar gene expression results with 3-DGE offering cost savings and scalability.