A multiscale chromatin collapse underlies vascular pathology in Hutchinson -Gilford progeria syndrome
Mzwanele Ngubo, Naveen Ahuja, Rana Karimpour, Amit Shrestha, Michael J. Hendzel, Theodore J. Perkins, William L. Stanford
This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.
bioRxiv · May 27, 2026 · PreprintGenomics